Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Seitz AE[original query] |
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Evaluating opioid analgesic prescribing limits: A narrative review
Seitz AE , Janiszewski KA , Guy GPJr , Tapscott RT , Einstein EB , Meyer TE , Tierney J , Staffa J , Jones CM , Compton WM . Pharmacoepidemiol Drug Saf 2022 31 (6) 605-613 PURPOSE: In response to the opioid crisis, opioid analgesic guidelines and prescribing limits have proliferated. The purpose of this narrative review is to examine evidence from studies evaluating the patient or public health impact of federal and state opioid analgesic prescribing guidelines and laws, describe gaps and challenges in current research, and highlight opportunities for improving future research. METHODS: We focused on evidence from a literature review covering 2013 through 2019. We identified 30 studies evaluating opioid analgesic thresholds based on federal policies and guidelines, state laws, and Medicaid state plans that attempt to influence the course of patient care at or when the limit is exceeded (e.g., prior authorization). RESULTS: Most studies evaluated changes in prescribing or dispensing patterns of opioid analgesics, largely finding decreases in prescribing after policy enactment. Fewer studies evaluated patient or public health outcomes beyond changes in prescribing and dispensing patterns; results were infrequently stratified by potentially important sociodemographic and clinical factors. No studies assessed the potential for adverse patient outcomes for which we have emerging evidence of harms. CONCLUSIONS: We describe knowledge gaps and propose opportunities for future research to sufficiently assess the potential impact and unintended consequences of opioid analgesic prescribing laws, regulations, guidelines, and policies. |
Anemia prevalence and trends in adults aged 65 and older: U.S. National Health and Nutrition Examination Survey: 2001-2004 to 2013-2016
Seitz AE , Eberhardt MS , Lukacs SL . J Am Geriatr Soc 2018 66 (12) 2431-2432 To the Editor: The prevalence of anemia is known to increase with age and is associated with negative health outcomes, including greater risk of hospitalizations and greater mortality.1 Anemia in older adults can be due to nutrient deficiencies, chronic kidney disease, chronic inflammation, or inflammatory disease or can be unexplained.2 Because of the potential health consequences and potentially changing prevalence of underlying causes, it is important to have updated national anemia estimates and trends over time for this population. |
Autonomic dysfunction and risk factors associated with Trypanosoma cruzi infection among children in Arequipa, Peru
Bowman NM , Kawai V , Gilman RH , Bocangel C , Galdos-Cardenas G , Cabrera L , Levy MZ , Cornejo Del Carpio JG , Delgado F , Rosenthal L , Pinedo-Cancino VV , Steurer F , Seitz AE , Maguire JH , Bern C . Am J Trop Med Hyg 2011 84 (1) 85-90 Chagas disease affects an estimated 8 million people in Latin America. Infected individuals have 20-30% lifetime risk of developing cardiomyopathy, but more subtle changes in autonomic responses may be more frequent. We conducted a matched case-control study of children in Arequipa, Peru, where triatomine infestation and Trypanosoma cruzi infection are emerging problems. We collected data on home environment, history, physical examination, electrocardiogram, and autonomic testing. Signs of triatomine infestation and/or animals sleeping in the child's room and household members with Chagas disease were associated with increased infection risk. Electrocardiogram findings did not differ between cases and controls. However, compared with control children, infected children had blunted autonomic responses by three different measures, the Valsalva maneuver, the cold pressor test, and the orthostatic test. T. cruzi-infected children show autonomic dysfunction, although the prognostic value of this finding is not clear. Sustained vector control programs are essential to decreasing future T. cruzi infections. |
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